What is Oestrogel?
Oestrogel 0.06% is a drug which contains 17B Estradiol which is medication used to treat symptoms of menopause including hot flashes and to treat dryness around vagina. It is also used in to treat the condition in women where their ovaries are not able to produce enough oestrogen naturally, this condition is known as Hypoestrogenism.
Estradiol is a natural form of hormone oestrogen, it works by replacing the oestrogen which is not naturally produced by the ovaries of the women.
Oestrogel is the medication which is available as the topical cream, transdermal gel which is applied once a day on the skin. It contains the active ingredient estradiol (Oestradiol) which occurs in women naturally, which is a female sex hormone.
Fig1: Oestrogel Pack
What is the use of Oestrogel?
Estradiol gel 0.06% is used in the HRT(Hormone Replacement Therapy) and in to relieve from the menopause symptoms. The Estradiol Gel contains oestrogen.
Progestrone is prescribed because oestrogen stimulates the growth of the womb lining (know as endometrium) which can cause cancer in womb area. It might not eradicate the risk of cancer completely. This type of medication is called combined HRT.
Estradiol also helps in the prevention of Osteoporosis. Osteoporosis is a condition which is known as postmenopausal women. The condition can increase the risk of fractures.
Women are usually considered to be on risk of developing fractures if they have faced menopause earlier, also in those with a family history of having osteoporosis and women who have very thin lining or smokers.
HRT supporting medications are:
- Premarin Cream (Conjugated Estrogen)
- Premarin 0.625 mg
- Susten 100mg Injection
- Susten Injection 200mg/1ml
- Susten 200mg Gelatin Capsule
- Utrogestan 200 mg Capsule
How does Estradiol Gel works?
Oestrogel contains the active ingredient Estradiol which develops secondary sexual characteristics such as development of Vagina and Breast. It occurs naturally in the ovaries of the female body.
When ovaries are unable to produce oestrogen in enough quantities, the symptoms of menopause start to occur. Decreasing the oestrogen level in the blood.
Decrease in estrogen level can cause irregular periods, hot flushes, mood swings & vaginal dryness.
Oestrogen can be given as a supplement in the form of Oestrogel. Thus replacing the falling levels of Estrogen in the body. This procedure is known as HRT (Hormone Replacement Therapy).
HRT works for a short term relief only, for a long term relief from menopause symptoms, you should visit your specialist at least twice an year.
HRT can sometimes be used to prevent osteoporosis in postmenopausal women. The gradual decline Oestrogen in women can cause bone fracture and bone loss. Oestrogel is drug which can give you relief from the these symptoms.
By applying on the skin and the Oestrogen is absorbed through the skin and enters into the bloodstream.
Contents of Oestrogel:
How can I use Oestrogel?
Fig3: Measuring Oestrogel
The amount of Estradiol Gel to be applied is 2.5 gm. The amount can be using the measured using the spatula that came with Oestrogel.
Fig4: Applying Oestrogel on the skin
- Oestrogel needs to applied on the clean, dry and unwounded skin once daily. It can be applied on the arms, shoulder or inner thigh part.
- Carefully measure the dose with the spatula provided with the Estradiol Gel. Do not overdose the medicine.
- Follow the instruction carefully.
- Let the gel dry out for minimum 5 minutes.
- Don’t apply the gel near breast, vagina or face.
- The gel is odourless.
- Avoid it from getting into your eyes.
- Do not use any strong skin cleanser.
- Avoid drinking alcohol
- Try to apply this medication at the same time daily.
The medicine it self have no side-effects but you face any problem, please contact your doctor immediately. Stop using the drug immediately if you face extreme pain around the stomach or sudden chest pain. Swelling around the leg region or unable to bear the pain or causing numbness or breathing problem.
Is it a perfect replacement for Progynon Depot / Estrofem?
As you know in early 2016, Progynon Depot was discontinued by Bayer Zydus. Many women were under this medication for quite long. By this action they were left in dark, unable to find the best suitable alternative to it.
Oestrogel 0.06% can be called the best alternative to Progynon Depot because, it is not required to be injected into the blood which eventually becomes quite painful after few time of injecting.
Secondly Oestrogel is odourless and does not cause any irritation which makes it the best alternative to Progynon Depot. You can read our blog about discontinuation of Estradiol Valerate Injection from here.
In case you have or suffering from any of the following then you should not apply the Oestrogel 0.06%?
You should not apply the Oestrogel if you are having the following problems:
- If you are allergic to the externally applied creams and gels.
- In past anyone in your family had carcinoma of the breast.
- Having liver any aliment
- Genital bleeding.
If you accidentally take high dose or double dose?
- Breast Tenderness
- Abnormal abdominal pain
- Adverse effect on Liver function
If you ever took high dose of the drug please contact emergency services immediately and seek medical help as soon as possible.
Interaction with the drug?
This is the list of medicines or medication which can decrease the effectiveness of the Oestrogel are as follows:
- Anticonvulsants such as Carbamezapin, Phenobarbital, Phenytoin.
- Anti-Infectives, such as Nevirapine, Efavirenz, Rifampicin and Rifabutin.
- Ritonavir and Nelfinavir for HIV.
- Preparations containing St John’s Wort, such as Hypericum Perforatum.
- Thyroid treatment medications such as Liothryonin, Liotrix, Levothryoxine etc.
- Antifungal medicines like Clarithomycin, Erythomycin, Isoniazid, Telithromyocin etc.
Before taking any new medicine in the case when you are under the course of Oestrogel then you should consult your physician.
I missed my dose?
If you have miss your dose take it immediately when you realise about it. Do not overdose or apply double dose as it can be dangerous for you. Contact emergency services immediately if you have taken the medicine twice at a time.
How to store Oestrogel?
Store the medicine in dark and cool place under 86 F or 30 C.
Risk of using Oestrogel:
When you take Estradiol externally, it can lead to some health risks such as:
- Vein Thrombosis
Do not apply this gel medication if you are more than 65 years of age.